A DISTAL INTERGENIC REGION CONTROLS PANCREATIC ENDOCRINE DIFFERENTIATION BY ACTING AS A TRANSCRIPTIONAL ENHANCER AND AS A POLYCOMB RESPONSE ELEMENT.

A distal intergenic region controls pancreatic endocrine differentiation by acting as a transcriptional enhancer and as a polycomb response element.

Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms.Gene activation is dependent enchanted taylor swift perfume on cell-specific transcription factors that recognize transcriptional enhancer sequences.Gene repression often depends on the recruitment of Polycomb group (PcG) p

read more


Insights into the molecular regulation of monolignol-derived product biosynthesis in the growing hemp hypocotyl

Abstract Background Lignin and lignans are both derived from the monolignol pathway.Despite the similarity of their building blocks, they fulfil different functions in planta.Lignin strengthens the tissues of the plant, while lignans are involved in plant defence and growth regulation.Their biosyntheses are tuned both spatially and temporally to su

read more

Successful Perioperative Combination of High-Dose FVIII Therapy Followed by Emicizumab in a Patient with Hemophilia A with Inhibitors

We managed perioperative hemostasis for a 72-year-old bible flask man with hemophilia A and low inhibitor titers (3 BU/mL), who underwent osteosynthesis for supracondylar fracture of the left humerus.He was treated perioperatively using the combination of high doses of factor VIII (FVIII) with recombinant human Factor VIII Fc fusion protein (rFVIII

read more